Pancreatic ?-Cell Senescence: Mechanisms and Association with Diabetes

Senescence occurs as a part of the cellular response to different stressors. With increasing age, continuous exposure stressors leads age-induced senescence. Pancreatic ?-cell proliferation and glucose homeostasis also decrease with which results in ? cell mass and, eventually, possible development diabetes. This process is mediated through impaired cycle regulators, along specific increases inhibitors, telomere shortening, defective DNA repair mechanisms. Diabetes contributes senescence hyperglycaemia, dyslipidaemia, oxidative stress, inflammation. cells isolated from patients Type 2 diabetes mellitus have been shown markers, such senescence-associated secretory phenotype genes ?-galactosidase. In this paper, authors discuss mechanisms senescence, how impacted by diabetic microenvironment, factors contributing